Effect of intensive bloodpressure treatment on patient. See the nejm article, a randomized trial of intensive. The sprint trial, funded by the nhlbi arm of the nih and cosponsored by the niddk, nimds and nia, was based on a working group report pdf link from 2007, which identified the question of targeting low blood pressure i. Find powerpoint presentations and slides using the power of, find free presentations research about sprint trial ppt.
We thank the editors of hypertension for the invitation to discuss aspects of the recently published systolic blood pressure intervention trial sprint. A randomized trial of intensive versus standard blood. National clusterrandomized trial of dutyhour flexibility in. Prepare to become a physician, build your knowledge, lead a health care organization, and advance your career with nejm group information and services. Promise trial publication in nejm march 2015 edition march 14, 2015 san diego the landmark trial of cardiovascular arena promise trial was the limelight of acc conference 2015 where the trial results were presented for the first time. The systolic blood pressure intervention trial sprint is a 2arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at reducing systolic blood pressure sbp to a lower goal than currently recommended will reduce cardiovascular disease cvd risk. Browse the entries and read the findings that were identified using the sprint trial data underlying the nejm article.
Blood pressure medications linked to serious falls. Original article from the new england journal of medicine a randomized trial of intensive versus standard bloodpressure control. Instead, says yusuf, the trial supports a broader but by no means universal approach to primary prevention. Justification for chronic kidney disease subgroup in sprint american society of hypertension 27th annual meeting, may 20. A randomized trial of intensive versus standard bloodpressure control.
Canagliflozin and cardiovascular and renal events in type 2. A multicenter, randomized, controlled clinical trial of. Whelton, mb, md, msc chair, sprint steering committee tulane university school of public health and tropical medicine, and school of medicine. Sprint mind trial finds lower risk of mci and dementia. The authors wrote the manuscript and vouch for the accuracy and completeness of the data and reporting of adverse events and for the fidelity of the trial to the protocol, available with the full text of this article at. Sprint challenge winning submissions nejm congratulates the winners selected from 143 entries worldwide. When trials of bloodpressurelowering drugs have shown benefits in patients without hypertension, these effects have often been ascribed to. New england journal of medicine challenged our ways of thinking.
New england journal of medicine publishes mindact trial. How does hope3 change thinking about primary prevention. The trial was terminated early after median followup of 3. Dec 2, 2015 addison a taylor, md sprint trial perspectives and analysis.
The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure. The systolic blood pressure intervention trial sprint randomized patients aged 50 years or more who had a systolic blood pressure sbp equal or greater than mm hg and a high cardiovascular risk to an antihypertensive treatment aimed at achieving an sbp of pdf. The sprint trial on intensive blood pressure management, published in november, redefines bloodpres sure target goals. The new england journal of medicine announces the sprint. Sprint trial clinical conversations nejm journal watch. The systolic blood pressure intervention trial sprint was designed to test the hypothesis that systolic blood pressure sbp reduction to a goal of less than 120 mm hg had a greater impact on fatal and nonfatal cardiovascular events than reducing sbp to the goal of trial sprint was designed to test the effect of more intensive bp control on cardiovascular primary end point, renal, and cognitive outcomes in persons without diabetes or preexisting stroke. Trial sprint research group is pro vided in the supplementary appendix, available at. The trial looked at treatment with steroids andor pentoxiphylline for patients with alcoholic hepatitis. Sep 21, 2010 the systolic blood pressure intervention trial sprint is a 2arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at reducing systolic blood pressure sbp to a lower goal than currently recommended will reduce cardiovascular disease cvd risk. Nov 09, 2015 during the trial, intensive and standardtreatment patients required averages of three and two drugs, respectively. Current guidelines have not been updated to reflect the results of this trial, and therefore recommendations are scant.
Supplementary appendix the new england journal of medicine. This paper describes the design of the systolic blood pressure intervention trial sprint, which aims to address this question. The purpose of the emphasishf trial was to explore the effects of adding eplerenone, a type of mineralocorticoid antagonist, to evidencebased therapy in patients with systolic heart failure and only mild symptoms i. Links to the sprint trial and to nejm resources and to www.
Aligning incentives web event the sprint data analysis. The nih systolic blood pressure intervention trial sprint, an nhlbisupported study, was designed to answer three important research questions about how treating to a lower systolic blood pressure targetless than 120 millimeters of mercury mm hgaffects the cardiovascular system, kidneys, and brain. The protect trial is another incredible anzics ctg effort, in conjunction with the canadian ctg. Use of vibrio cholerae vaccine in an outbreak in guinea. Feb 11, 1999 a multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Promise trial publication in nejm march 2015 edition. A precise study of pregabalin for sciatica nejm resident 360. A trial coordinating center served as a data and biostatistical core. The ninds trial demonstrated improvements in functional outcomes at 3 months if thrombolysis was administered within 3 hours of symptom onset, with the greatest benefit seen within 90 minutes. Lee ay, bauersachs r, janas ms, jarner mf, kamphuisen pw, meyer g, khorana aa.
Prednisolone or pentoxifylline for alcoholic hepatitis nejm. A phase 3 randomized trial of voxelotor in sickle cell disease. Participate in online discussions about sharing clinical trial data. Nov 09, 2015 learn results from the sprint trial on intensive blood pressure management in less than 2 minutes with new nejm quick take video summary. Benazepril plus amlodipine or hydrochlorothiazide for. The trial studied persons with a systolic blood pressure of greater than mm hg and increased cardiovascular risk.
Blood pressure target should be 120, sprint data show. The systolic blood pressure intervention trial sprint recently reported that participants assigned to an intensive sbp treatment target of less than 120 mm hg vs the standard sbp treatment goal of less than 140 mm hg had a 25% lower relative risk of major cardiovascular events and death, and a 27% lower relative risk of death from any cause. Originally published in 2012, the einsteinpe trial was a randomized, openlabel, noninferiority trial involving 4,832 patients. Today the sprint trial results are finally being published in the new england journal of medicine. The race to treat atrial fibrillation in the emergency department. Antihypertensive drug management to achieve systolic blood. Justification for chronic kidney disease subgroup in sprint. The sprint study, suggesting that we aim for a systolic bp target of 120 mm hg in highrisk hypertensive patients, has been published with much fanfare. Redefining bloodpressure targets sprint starts the marathon. Hebert pc1, wells g, blajchman ma, marshall j, martin c, pagliarello g, tweeddale m, schweitzer i, yetisir e. Register today at what did we learn about data sharing from the sprint challenge. Systolic blood pressure intervention trial sprint principal results paul k. The new england journal of medicine benazepril plus amlodipine or hydrochlorothiazide for hypertension to the editor. Ticagrelor with or without aspirin in highrisk patients.
Based on the results of atn and similar studies, threetimes weekly ihd with target ktvurea of 1. This happened recently in one of my private er visits. View and download powerpoint presentations on sprint trial ppt. The results of the stopah trial have been published in the new england journal of medicine. Original article from the new england journal of medicine prednisolone or pentoxifylline for alcoholic hepatitis. Aligning incentives for sharing clinical trial data. In a doubleblind trial, we examined the effect of ticagrelor alone as compared with ticagrelor plus aspirin with regard to clinically relevant bleeding among patients who were at high risk for bleeding or an ischemic event and had undergone pci.
Nejm publishes two more trials weakening the case for pfo. Nejm announces sprint data analysis challenge nejm group. May 03, 2007 heart outcomes prevention evaluation3 hope3 the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. In their report on the avoiding cardiovascular events through combination ther apy in patients living with systolic hypertension accomplish trial, jamerson et al. New data from a major study called sprint, released monday, has shaken some of the basic assumptions about the treatment of high blood pressure. The trial found that lowering systolic blood pressure from currently recommended levels of 140 to 150 to below 120 could prevent heart attacks and strokes and potentially save many lives. Sprint challenge will demonstrate the potenfial of sharing of clinical trial data. Nov 09, 2015 do published sprint study results live up to premature nih news release hype. A primary cardiovascular prevention trial in people at intermediate risk allan s.
Pdf a randomized trial of intensive versus standard blood. To explore the potential of clinical trial data sharing, the new england journal of medicine nejm is hosting a challenge. Transfusion requirements in critical care investigators, canadian critical care trials group. Systolic blood pressure intervention trial sprint professional. Editorial from the new england journal of medicine a sprint to the finish. Randomized trial of three anticonvulsant medications for. Atrial fibrillation is an increasingly common reason for presentation to the emergency department, representing nearly 0. Notable articles of 2019 the new england journal of medicine. Despite a tenfold increase in symptomatic intracranial hemorrhage ich, there was no significant difference in mortality among those receiving tpa. Costeffectiveness of intensive versus standard bloodpressure. Generalizability of the sprint results nejm journal watch. Apr 26, 2016 posts about stream trial nejm written by dr s venkatesan. The new england journal of medicine announces the sprint data analysis challenge sprint challenge will demonstrate the potential of sharing of clinical trial data boston, mass. The systolic blood pressure intervention trial sprint randomized patients aged 50 years or more who had a systolic blood pressure sbp equal or greater than mm hg and a high cardiovascular risk to an antihypertensive treatment aimed at achieving an sbp of sprint is a twoarm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at reducing systolic blood pressure to a lower goal than currently recommended will reduce cardiovascular disease risk.
The addition of pertuzumab to standard trastuzumab therapy in patients with early her2positive breast cancer led to modest improvements and increased side effects in the aphinity trial. A randomized trial of intensive versus standard bloodpressure. Compass trial shows rivaroxaban with aspirin improves stable. Learn results from the sprint trial on intensive blood pressure management in less than 2 minutes with new nejm quick take video summary. The new engl and journal of medicine 2546 n engl j med 358. Read the sprint challenge submissions sprint data analysis challenge is. Heart outcomes prevention evaluation3 full text view.
This finding is certain to unsettle further the ongoing discussion about what patients and their doctors should do about this common risk factor mildly elevated blood pressure and runs counter to the findings of the sprint trial, albeit with a different population and lessaggressive treatment nejm jw gen med dec 15 2015 and n engl j. The multicenter systolic blood pressure intervention trial sprint now provides some guidance. Eligible patients were those who had an acute, symptomatic pe with or without symptomatic deepvein thrombosis dvt. Original article from the new england journal of medicine canagliflozin and cardiovascular and renal events in type 2 diabetes. Abstr act a randomized trial of intensive versus standard bloodpressure control the sprint research group original article the new england journal of medicine downloaded from on november 9, 2015. Aug 25, 2016 new england journal of medicine publishes mindact trial results proving the clinical utility of mammaprint in assisting physicians to identify earlystage breast cancer patients who can safely forgo chemotherapy. Do published sprint study results live up to premature nih.
Listing a study does not mean it has been evaluated by the u. Sprint was a randomized, controlled, openlabel trial that was conducted at 102 clinical sites organized into 5 clinical center networks in the united states, including puerto rico see the supplementary appendix, available with the full text of this article at. Ambrosius wt, sink km, foy cg, et al sprint study research group. Is aphinity the end of the line for trastuzumab addons. This 3764 participant, db, mulitcentre, international, rct, compared dalteparin to unfractionated heparin in adult icu patients exclusions included orthopaedic, neurosurgery, major trauma with proximal dvt detected by twice weekly compression ultrasound the primary outcome. A complete list of the members of the systolic blood pressure intervention trial sprint research group is provided in the supplementary appendix, available at. Systolic blood pressure intervention trial sprint study. Notable articles of 2015 the new england journal of. Systolic blood pressure intervention trial full text view. A primary cardiovascular prevention trial in people.
The systolic blood pressure intervention trial sprint. When i asked my fellow to lyse a patient with stemi who arrived within 20 minutes after the onset of chest pain to our ccu. The trial design and primary results have been published previously. The new england journal of medicine 2112 n engl j med 370. Apr 02, 2016 salim yusuf, the principal investigator of hope3, says that the trial does not support the case for universal primary prevention, or widespread use of a polypill, or the put statins in the water school of thought.
The sprint data analysis challenge resulted in 144 submissions to the challenge. Effect of intensive bloodpressure treatment on patientreported. Antihypertensive drug management to achieve systolic blood pressure sprint introduction since the cardiovascular results of sprint have been announced to the public and the study participants, we believe that there may be interest among health professionals on the approach used. People with type 2 diabetes are at elevated risk for a number of seri. The sprint trial, published nov 9 in the new england journal of medicine, is the biggest news in blood pressure treatment in many years. The nih systolic blood pressure intervention trial sprint, an nhlbisupported study, was designed to answer three important research questions about how treating to a lower systolic blood pressure targetless than 120 millimeters of mercury mm hgaffects the. A substudy of the sprint trial which randomized patients to either a standard group, with a target of less than 140 mm hg, or an intensivetreatment group, with a target of less than 120 mm hg sprint mind looked at 9,361 hypertensive older adults with increased cardiovascular risk but without diagnosed diabetes, dementia or stroke. A trial on peanut allergy, published in february, indicates that allergen avoidance is not the way to prevent allergy in young children. September 28, 2016 to demonstrate the potential of sharing clinical trial data to develop undiscovered research findings, the new england journal of medicine nejm is sponsoring. Sep 12, 2017 september 12, 2017 rivaroxaban plus aspirin improves survival and reduces stroke and heart attack in patients with stable coronary or peripheral artery disease, according to latebreaking results from the compass trial presented in a hot line latebreaking clinical trials session at the 2017 european society of cardiology esc congress and published in the new england journal of medicine. The goal for the sprint challenge was to explore what could be achieved by sharing clinical trial data, and to bring trialists, data analysts and patients together for a constructive conversation.
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